News & Events

26 March 2025

More than 300 experts have joined the Liver Health Helix

Whohoo! By March 2025, more than 300 experts from 140 organisations in 38 countries have joined the Liver Health Helix. Launched in 2021 to support the dissemination and impact of A-TANGO, the Helix is an international open innovation community of specialists in the fields of liver disease, in particular, from cirrhosis research, general hepatology, drug manufacturing, bioinformatics, and related disciplines. The Helix supports A-TANGO's ambition to develop a novel therapy for liver failure, also called acute-on-chronic liver failure (ACLF), and is managed by Burcu Kiper from A-TANGO partner Crowdhelix (CHX). Please click here to create an account and then search for and join the "Liver Health Helix".

12 March 2025

Masterclass about Clinical Trial Design

Who truly conducted the first clinical trial can be debated, but historical records suggest it happened in biblical times. Prof. Cornelius Engelmann (MD, PhD) from the Charité - Universitätsmedizin Berlin, who supervises the clinical G-TAK trial of A-TANGO, will give an all-encompassing Masterclass lecture about "Clinical Trial Design - Strategies, Procedures, Pitfalls & Lessons Learned from A-TANGO" for invited participants, clinicians, and early-career scientists (ECS) of the A-TANGO and DECISION-Project on Wednesday, 26 March 2025, from 4-5 pm CET. Selected slides from his presentation will be available for download from the "Training & E-Learning" page after the event - stay tuned!

10 January 2025

Troels Jordansen becomes new CEO of Yaqrit

Yaqrit welcomes Troels Jordansen as its new CEO. With over 30 years of international healthcare experience spanning pharmaceuticals, medical devices, cellular therapy, and biotech, Troels brings a strong commercial background in sales, marketing, investor relations, and business development. Having co-founded start-ups and led public companies, he has raised over €200 million in funding and closed deals exceeding €500 million. His global expertise will also be instrumental in driving A-TANGO’s innovation. Read the related press release.

OUR VISION

More than 10 million people worldwide suffer from decompensated cirrhosis, often as a result of severe alcoholic hepatitis (sAH) or other chronic liver diseases. In its final stages, decompensated cirrhosis leads to acute-on-chronic liver failure (ACLF), a syndrome characterized by multi-organ failure. Effective treatment of ACLF is an urgent and unmet need. The A-TANGO consortium performs Phase 2 clinical studies of an innovative therapeutic strategy that targets inflammation and improves hepatocyte proliferation. We call this novel combinatorial therapy G-TAK. In addition, A-TANGO strives to identify reliable biomarkers for better patient stratification and an increased survival rate.

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OBJECTIVES

  • Obtain ethical and regulatory approval of the planned clinical studies
  • Ensure safe and regulated supply of the required drugs and placebos
  • European multicenter clinical study to establish the safety, pharmacokinetics, and efficacy of our novel therapeutic strategy
  • Explore the pathophysiological mechanisms and evaluate biomarkers
  • Evaluate our results with respect to clinical outcome, treatment impact, and quality of life
  • Exploit our results by identifying economic benefits for the healthcare system, reimbursement strategies, and potential commercial interest
  • Disseminate the therapeutic potential of our novel treatment strategy to stakeholders and increase awareness of end-stage liver disease

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SCIENTIFIC COORDINATOR

Prof. Dr. Rajiv Jalan (EF CLIF)
Av. Diagonal 477, 11th floor
08036 Barcelona
Spain

CLINICAL STUDY SUPERVISOR

Dr. med. Cornelius Engelmann (MD, PhD) (Charité)
Augustenburger Platz 1
13353 Berlin
Germany

PROJECT
MANAGEMENT

concentris research management gmbh
Ludwigstr. 4
82256 Fürstenfeldbruck
Germany