European Foundation for the Study of Chronic Liver Failure
Prof. Dr. Rajiv Jalan
Prof. Dr. Vicente Arroyo
Dr. Anna Bosch Comas
Cristina Sánchez Garrido
The European Foundation for the Study of Chronic Liver Failure (EFCLIF) was created with the aim of designing, promoting and supporting studies on the mechanism, prevention and treatment of liver cirrhosis and its complications; particularly, acute-on-chronic liver failure. EFCLIF is a non-profit organization committed to fight against a disease that represents the seventh most common cause of death in Western Europe.
EFCLIF has planned and organized three large (1200 – 1400 patients) multi-center (30-60 centers) observational studies in the field, with sequential sampling (CANONIC, PREDICT and ACLARA). One further large global study (including Europe, Asia, America and Australia) is in the phase of preparation. Moreover, EFCLIF has planned, prepared and executed investigator-initiated interventional studies, of which one study is completed. The studies of four further investigator-initiated trials have already started within the H2020 projects. The dedicated data management and analysis center is highly experienced with management of those studies and analysis of patients and omics data. The CANONIC study was the pioneer study within the field with regards to the sequential and extensive sampling of the patients.
Within A-TANGO, EFCLIF coordinates the project (WP8), and will lead the data management activities of the clinical study (WP5). Moreover, EFCLIF will participate in the study design, conduct and statistical analysis of the proof-of-concept trial described in WP1, WP2 and WP3.