This section keeps you updated on any major developments throughout the course of the A-TANGO project. For A-TANGO info brochures (in various languages), press releases, posters, and more, please visit the Downloads page. To receive our half-yearly newsletter, subscribe here!
27 November 2023
3-min survey about the effects of macroeconomic challenges on research in Europe
European researchers, especially project coordinators & supervisors of clinical trials, are asked to answer a few questions to help us understand how COVID-19, inflation, lack of qualified human resources, and other macro-economic factors and challenges have affected your research in the past 4 years: Click here to access the survey. It only takes 3 minutes to complete the survey and participation is entirely anonymous (unless an email address is entered at the end to receive the results of the survey once they are ready). We intend to collect more than 100 responses before closing the survey. – Thank you kindly for supporting our initiative!
26 September 2023
3rd A-TANGO GA Meeting – remote
A-TANGO’s 3rd General Assembly (GA) Meeting took place via Zoom on Tuesday, 26 September 2023. We heard about everyone’s progress and the details of the planned start of the clinical G-TAK study. Besides updates on all work packages (WPs), we also discussed current financial issues and decided on mitigation measures to move the project forward. The early-career scientists (ECS) programme was a highlight again! Prof. Isabelle Durand-Zaleski (APHP) gave a fascinating and insightful Masterclass lecture on “Health Economics in Liver Disease” and Annarein Kerbert (LUMC) presented the progress of the ancillary studies and related manuscripts.
28 June 2023
Successful 5th Steering Committee Meeting
Two years and four months into the project, A-TANGO has overcome tremendous challenges and is coming closer to enrolling the first late-stage cirrhosis patient into the clinical “G-TAK” study in autumn. At today’s 5th Steering Committee Meeting (28 June), we realized how far we’ve come and that we may just get to tackle that very serious disease, called acute-on-chronic liver failure (ACLF). A big thank you to the whole team for all your hard work! Big efforts often require tough decisions, but what counts most is that the entire consortium is committed to bringing this novel combinatorial therapy to those who desperately need it – the patients.
22 June 2023
Symposium on late-stage cirrhosis treatment at EASL Congress on Saturday
With 9000 participants from 120 countries & 2500 submitted abstracts, “EASL Congress 2023” is already a success again. Don’t forget to attend this symposium on “Novelties in the therapeutic landscape for acute decompensation of cirrhosis” on Saturday, 24 June 2023 from 8:30 – 09:45 CEST (room: Strauss 1). A-TANGO coordinator Prof. Rajiv Jalan from EF CLIF, Dr. Minneke Coenraad from Leiden University Medical Center (LUMC), and Dr. Cornelius Engelmann from the Charité will discuss their insights, including A-TANGO’s G-TAK study.
21 June 2023
A-TANGO members’ sessions at EASL Congress – swing by!
A-TANGO scientists host sessions and present their work at “EASL Congress 2023” in Vienna, Austria. Come and visit Dr. Annarein Kerbert from Leiden University Medical Centre (LUMC) at her poster on Thursday, 22 Jun, 16:15 – 16:21 (room: Track hub “Cirrhosis & complications”), join the poster tour by Dr. Cornelius Engelmann from the Charité on Friday, 23 June, from 10:00 – 10:30 (room: Track hub “Metabolism, alcohol & toxicity”), and listen to EASL Secretary General Prof. Dr. Thomas Berg from Leipzig University Medical Center (ULEI) during the EASL Studio on Friday, 23 June, from 12:30 – 13:00 (room: Hepatology Arena).
15 December 2022
Press Release on Engelmann et al. 2022 paper
What’s the scientific basis for our new combinatorial treatment of acute-on-chronic liver failure (ACLF)? This new press release by the European Foundation for the Study of Chronic Liver Failure (EF CLIF) about the recently published study by Dr. med. Cornelius Engelmann and colleagues in the Journal of Hepatology gives answers!
14 November 2022
Have a look at our most recent newsletter
Have a look at our 2nd newsletter – The first research period of A-TANGO has been completed, the report has been submitted to the European Commission (EC), new Masterclasses and interview videos are on YouTube, and we have a new project manager. You can access previous newsletters, flyers, posters, templates, and more on the Downloads page.
10 November 2022
4th SC Meeting on 29 November 2022 (remote)
Save the date – The 4th Steering Committee (SC) Meeting will take place on Tuesday, 29 November 2022, online (via Zoom) from 9 am – 4 pm CET. Check your inbox for details from the project management office. We are very much looking forward to seeing you all soon, if not in person, then at least on-screen! You can register here on the A-TANGO Meetings page.
31 October 2022
1st periodic report submitted
The project’s periodic report has just been submitted to the European Commission (EC). Read about A-TANGO’s progress in our public summary of the 1st research period (1st of March 2021 – 31st of August 2022). You can also download the summary from the Downloads page. The report contains the results of all work packages (WPs) so far, as well as the progress beyond the state of the art, expected results until the end of the project, and their potential impact and societal benefit.
24 October 2022
Free access to EASL educational tools for A-TANGO trainees
All A-TANGO early-career scientists (ECS) can now benefit from EASL’s extensive educational tools and the Young Investigators (YI) community. EASL campus is currently open access for individuals with a MyEASL account. Soon, some of the content will be restricted to EASL members. Therefore, EASL invites the project’s ECS to create a MyEASL account and request a complimentary membership. Feel free to contact Wouter Kruijs (Association & Community Services Manager at EASL) if you have questions. More info.
25 September 2022
Masterclass by Thomas Berg now online
In our newest Masterclass on YouTube, Prof. Dr. Thomas Berg, Head of Hepatology at ULEI and Secretary General of EASL, provides an in-depth overview of the current clinical challenges and newest treatment advances for patients suffering from cirrhosis and ACLF. The Masterclass was recorded during the 2nd A-TANGO General Assembly (GA) Meeting in Barcelona, Spain, on 11 May 2022. More E-Learning.
22 September 2022
Watch our video series from #ILC2022
Following the patients’ interest in A-TANGO, we experimented with a new communication format during the International Liver Congress (#ILC2022) in London in June 2022 and recorded several video interviews by representatives of the European Liver Patients’ Association (ELPA) with Dr. med. Cornelius Engelmann (Charité), co-coordinator of A-TANGO and supervisor of the clinical G-TAK study. Watch the videos!
10 August 2022
1st official A-TANGO publication
Our J Hep article by Engelmann et al. (2022) highlights the scientific basis of A-TANGO and the therapeutic potential of the G-TAK therapy for improved outcomes in cirrhosis and ACLF patients – a definite must-read. The authors demonstrated, using mouse models, that the combination of G-CSF (which can promote liver regeneration) and TAK-242 (which inhibits a receptor that plays a key role in inflammation) could be effective for the treatment of ACLF. Recruitment for the study starts in 2023 – stay tuned!
8 August 2022
Masterclass by Daniel Green on YouTube
Daniel Green – project partner, entrepreneur, and CEO of Yaqrit (YAQ) – held an interactive and fun Masterclass on “Medical Device Design, Biotechnology and Entrepreneurship” during the 2nd A-TANGO General Assembly (GA) Meeting in Barcelona, Spain, on 11 May 2022. The Masterclass is now available on YouTube. If you want to learn more, check out our E-Learning page.
24 June 2022
Meet us at #ILC2022 on Friday, 24 June 2022
Don’t miss the opportunity to meet the A-TANGO team and receive important information about the project, the clinical trial, and its sister Horizon 2020-funded projects DECISION and MICROB-PREDICT during the International Liver Congress (#ILC2022) in London. Come find us near the EASL Community Hub on Friday, 24 June 2022, from 12-13h GTM.
28 January 2022
A-TANGO at Falk Symposium on Alcoholic Liver Disease
From 27-28 January 2022, the Falk Foundation Symposium on the “Pathophysiology and Clinical Management of Alcoholic Liver Disease” took place in a registration-based online format. A-TANGO coordinator, Prof. Rajiv Jalan (EF CLIF, UCL, HPX), presented a talk on “Mechanisms of recovery from and strategies for survival of severe alcoholic hepatitis and ACLF” and discussed important unsolved questions regarding the recovery from cirrhosis and episodes of ACLF.
22 December 2021
Scroll through our 1st newsletter and meet our early-career scientists
The 1st A-TANGO newsletter is out – Learn about the project’s progress, our early-career scientists (ECS), this year’s patient event about cirrhosis and ACLF, and upcoming scientific conferences. If you haven’t received our newsletter in your inbox, but would like to stay updated on a half-yearly basis via email, please subscribe here. Let us wish you all Happy Holidays & a healthy New Year!
30 November 2021
A-TANGO info brochure now available in 4 more languages
The A-TANGO info brochure is now available in 4 more languages (DE, ES, FR, NL), each in a print + web version. Feel free to download, print, and share! We are getting ready for the G-TAK study to treat ACLF, occurring in late-stage cirrhosis, and will use the info brochure to inform patients participating in the study, as well as their relatives, about the bigger scope of the A-TANGO project. A big thank you goes out to the volunteer translators within the consortium!
20 September 2021
Successful 2nd SC Meeting
Congrats to all work package leaders for the great progress made on their tasks, and for the detailed updates and presentations during the 2nd Steering Committee (SC) Meeting on 20 September 2021. The preparations for getting 30 European liver centres on board, receiving all necessary ethics approvals, and setting up the clinical trial (including manufacturing the drugs for the combinatorial G-TAK therapy) are at full speed. Although we had lots of fun on Zoom, we still can’t wait to meet in person soon. Hopefully, for the 2nd General Assembly (GA) meeting next year!
2 September 2021
Cornelius Engelmann introduces A-TANGO on YouTube
Watch this introductory video about A-TANGO. It is a recording of a joint patient event that informed the liver patient community in Europe about A-TANGO and two related Horizon 2020-funded cirrhosis projects, namely DECISION and MICROB-PREDICT. At the beginning of the video, the project’s scientific coordinator, Prof. Dr. Rajiv Jalan, emphasises the urgent need of novel therapies for late-stage cirrhosis, before the clinical study supervisor, Dr. Cornelius Engelmann, explains the details of the new combinatorial therapy ‘G-TAK’ that A-TANGO tests.
27 August 2021
Invitation to join the Liver Health Helix
The ‘Helix’ will form a community hub of peers that allows you to collaborate and also follow the A-TANGO project’s progress, activities, and results. Within the Helix, you can share and join specific collaboration opportunities related to cirrhosis, ACLF, and liver health. You can also invite stakeholders outside of the network who may be interested in this field. Join the Liver Health Helix and click “Follow”. You will then be notified of new opportunities according to your chosen interests.
30 June 2021
Stakeholder Map & Dissemination Plan ready
We have developed both the “Stakeholder Map” (D7.1) as well as the Dissemination & Communication Plan” (D7.2), outlining in detail the communication strategy, responsibilities, and target release dates. The deliverable reports are confidential but available for download from the intranet for all project members.
17 March 2021
Successful Kick-off Meeting
A-TANGO successfully kicked off in form of an online meeting on 17th March 2021. Consortium members outlined the work ahead over the next 12 months, elected the Impact Board (IB), made first decisions, and incorporated valuable feedback from the scientific and ethical advisory board (SEAB). A welcome break from all the science was a trivia quiz during a 10 min break in the afternoon!
1 March 2021
A-TANGO starts today
On 1st March 2021, the 5-year long, pan-European research project begins. All of us are excited to roll up our sleeves and get to work! A total of eight work packages (WPs) will cover the entire value chain of research and development, from discovery to clinical validation and market preparation. We are looking forward to meet all project members at the virtual kick-off meeting on 17th March 2021.