G-TAK – A NOVEL COMBINATORIAL THERAPY FOR ACUTE-ON-CHRONIC LIVER FAILURE

project duration

5.0 years

grant amount

6.0 million €

8 countries

14 institutions

kick-off

1st March 2021
More than 10 million people worldwide suffer from decompensated cirrhosis, often as a result of severe alcoholic hepatitis (sAH) or other chronic liver diseases. In its final stages, decompensated cirrhosis leads to acute-on-chronic liver failure (ACLF), a syndrome characterised by multi-organ failure. Effective treatment of ACLF is an urgent and unmet need. The A-TANGO consortium performs Phase II clinical studies of an innovative therapeutic strategy that targets inflammation and improves hepatocyte proliferation. We call this novel combinatorial therapy G-TAK. In addition, A-TANGO strives to identify reliable biomarkers for better patient stratification and an increased survival rate.

objectives

  • Obtain ethical and regulatory approval of the planned clinical studies
  • Ensure safe and regulated supply of the required drugs and placebos
  • European multicentre clinical study to establish the safety, pharmacokinetics, and efficacy of our novel therapeutic strategy
  • Explore the pathophysiological mechanisms and evaluate biomarkers
  • Evaluate our results with respect to clinical outcome, treatment impact, and quality of life
  • Exploit our results by identifying economic benefits for the healthcare system, reimbursement strategies, and potential commercial interest
  • Disseminate the therapeutic potential of our novel treatment strategy to stakeholders
  • Increase awareness of end-stage liver disease

Impact

Scientific
coordination

European Foundation for the Study of Chronic Liver Failure (EFCLIF)
Prof. Dr. Rajiv Jalan
Travessera de Gràcia 11, 7th floor
08021 Barcelona, Spain

Principal
Investigator

Charité – Universitätsmedizin Berlin (CHARITÉ)
Dr. med. Cornelius Engelmann
Augustenburger Platz 1
13353 Berlin, Germany

Project
management

concentris research management GmbH
Fürstenfeldbruck, Germany
Phone: +49 8141 6252 8570
Email: info@atango.eu

Project partners